Seksjob menen. Although no significantly enriched genes were found in vitro, 40 were found in the in vivo screens Extended Data Fig. Immunity 54 , —
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Several inhibitors that block menin—MLL interactions have entered clinical development in acute myeloid leukemia 25 ,
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A similar effect was also observed in the syngeneic breast cancer model 4T1, with increased and decreased tumor growth upon Men1 knockout in immunodeficient and immunocompetent mice, respectively Extended Data Fig. Subjects Cancer microenvironment Tumour immunology.